Shock exit for Scot
Konta faces Williams as Murray plans next move
Conta, the last remaining Brit in the tournament, is seeded ninth and saw off 30th seed Makarova 6-1 6-4.
She has never played the 22-time Grand Slam champion who will prove her biggest test yet.
Konta, who was born in Australia, won her second WTA title in Sydney and last year reached the Open semi-finals.
Andy Murray‘s hopes of winning a first Australian Open title were crushed after he lost to the world number 50 Mischa Zverev.
His German opponent won the fourth round tie 7-5 5-7 6-2 6-4 in what is the Scot’s earliest exit in Melbourne since 2009.
Murray will head home to decide whether to play in Britain’s Davis Cup tie in Canada next month, or take a break.
After wrapping up the match in three hours and 33 minutes Zverev progresses to the quarter finals where he will face Roger Federer who beat Kei Nishikori.
Zverev employed an attacking style against Murray, winning 65 points at the net and unnerving the Briton on his second serve.
After five losing finals in this tournament, Murray will have seen this as his best chance of lifting the title following the surprise defeat of six-times champion Novak Djokovic in the second round.
Speaking after his defeat to Zverev in the Rod Laver Arena, he said: “He deserved to win because he played great when he was down, and also in the important moments.”
Former Grand Slam champion Martina Navratilova said “mental tiredness” may have contributed to the Scot’s defeat after the strain and effort he employed in the second half of last year.
Fellow Briton Dan Evans was beaten by the French number one Jo-Wilfried Tsonga 6-7 6-2 6-4 6-4.
> Defending women’s single champion and world number one Angelique Kerber followed Murray out of the competition in the fourth round after being beaten in straight sets by Coco Vandeweghe.
The form book has gone out of the window at Melbourne Park this year, with Agnieszka Radwanska and Simona Halep also suffering early defeats.
Vandeweghe saw off off Kerber 6-2 6-3.